Life extension is the concept of extending the human lifespan, either modestly through improvements in medicine or dramatically by increasing the maximum lifespan beyond its generally-settled limit of 125 years. Several researchers in the area, along with “life extensionists”, “immortalists” or “longevists” (those who wish to achieve longer lives themselves), postulate that future breakthroughs in tissue rejuvenation, stem cells, regenerative medicine, molecular repair, gene therapy, pharmaceuticals, and organ replacement (such as with artificial organs or xenotransplantations) will eventually enable humans to have indefinite lifespans (agerasia) through complete rejuvenation to a healthy youthful condition. The ethical ramifications, if life extension becomes a possibility, are debated by bioethicists.

The sale of purported anti-aging products such as supplements and hormone replacement is a lucrative global industry. For example, the industry that promotes the use of hormones as a treatment for consumers to slow or reverse the aging process in the US market generated about $50 billion of revenue a year in 2009. The use of such hormone products has not been proven to be effective or safe.

Aubrey David Nicholas Jasper de Grey (/dəˈɡreɪ/; born 20 April 1963) is an English author and biomedical gerontologist. He is the author of The Mitochondrial Free Radical Theory of Aging (1999) and co-author of Ending Aging (2007). He is known for his view that medical technology may enable human beings alive today not to die from age-related causes.As an amateur mathematician, he has contributed to the study of the Hadwiger–Nelson problem in geometric graph theory, making the first progress on the problem in over 60 years.

De Grey is an international adjunct professor of the Moscow Institute of Physics and Technology, a fellow of the Gerontological Society of America, the American Aging Association, and the Institute for Ethics and Emerging Technologies. He has been interviewed in recent years in a number of news sources, including CBS 60 Minutes, the BBC, The Guardian, Fortune Magazine, The Washington Post, TED, Popular Science, Playboy, The Colbert Report, Time, the Skeptics’ Guide to the Universe, and The Joe Rogan Experience. He was the Chief Science Officer of the SENS Research Foundation, but was fired in August 2021 after allegedly interfering in a probe investigating sexual harassment allegations against him. In late 2022, de Grey co-founded Longevity Escape Velocity Foundation as President and Chief Science Officer.

Raymond Kurzweil (/ˈkɜːrzwaɪl/ KURZ-wyle; born February 12, 1948) is an American computer scientist, author, inventor, and futurist. He is involved in fields such as optical character recognition (OCR), text-to-speech synthesis, speech recognition technology, and electronic keyboard instruments.

He has written books on health, artificial intelligence (AI), transhumanism, the technological singularity, and futurism. Kurzweil is a public advocate for the futurist and transhumanist movements and gives public talks to share his optimistic outlook on life extension technologies and the future of nanotechnology, robotics, and biotechnology.

David Andrew Sinclair AO (born June 26, 1969) is an Australian-American biologist and academic known for his research on aging and epigenetics. Sinclair is a professor of genetics at Harvard Medical School and is the co-director of its Paul F. Glenn Center for Biology of Aging Research. He is the president of the non-profit Academy for Health & Lifespan Research and an officer of the Order of Australia (AO).

Peter H. Diamandis (/ˌdiːəˈmændɪs/ DEE-ə-MAN-diss; born May 20, 1961) is an American marketer, engineer, physician,[1] and entrepreneur of Greek-American ethnicity. He is best known for being founder and chairman of the X Prize Foundation, cofounder and executive chairman of Singularity University and coauthor of The New York Times bestsellers Abundance: The Future Is Better Than You Think, The Future is Faster than You Think, How Converging Technologies Are Transforming Business, Industries, and Our Lives and BOLD: How to Go Big, Create Wealth, and Impact the World.

He is former CEO and cofounder of the Zero Gravity Corporation, cofounder and vice chairman of Space Adventures Ltd., founder and chairman of the Rocket Racing League, cofounder of the International Space University, cofounder of Planetary Resources, cofounder of Celularity, founder of Students for the Exploration and Development of Space, vice chairman and cofounder of Human Longevity, Inc.